Levetiracetam

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Abstract
▲ Levetiracetam is an ethyl analogue of the nootropic agent piracetam. ▲ Results from rodent studies indicate that the drug may offer protection against absence, generalised and partial seizures. ▲ Levetiracetam exhibits linear pharmacokinetics and has a wide therapeutic index. Its potential to interact with other anticonvulsants appears to be low. ▲ Initial findings from a total of 29 patients with treatment-refractory epilepsy suggest that levetiracetam may be beneficial in patients with partial seizures. These results require confirmation. ▲ Somnolence and asthenia were the most common adverse events reported in patients receiving levetiracetam 1000 to 4000 mg/day; these appeared to be dose-related.