STUDIES ON DIABETES INSIPIDUS

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Abstract
Diuretic substances have been demonstrated in the urine of dogs with experimental diabetes insipidus and in extracts of large quantities of the mammillary bodies and thalamus of the brains of normal animals, which are presumably identical with the diuretic substance peculiar to the blood and to extracts of the mammillary bodies of the brains of dogs with experimental diabetes insipidus. These substances are destroyed by ashing. They are not soluble in ether, acetone or 95 % ethyl alcohol, and are not precipitated by phosphotungstic acid. The diuretic substance in the extracts of the mammillary bodies is destroyed by strongly alkaline solutions at room temp., and precipitated from solution by Ba (OH)2 at a p H of approximately 9.0. The diuretic substance in active preparations of the blood of dogs with experimental diabetes insipidus is likewise destroyed by strongly alkaline solutions at room temp. and is precipitated from solution by Ba(OH)2 in less strongly alkaline solution.

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