Biological studies with low and high molecular weight inhibin preparations

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Abstract
The effects of both high and low MW inhibin preparations on [rat] testicular and pituitary receptors were studied. Both these preparations were able to inhibit the binding of labeled h[human]FSH to testicular receptor in a dose related manner, but were unable to affect the binding of labeled hCG to its receptor, suggesting that the observed inhibition of FSH binding was specific to inhibin. The binding of LHRH to pituitary receptors was affected by inhibin preparations. Interestingly, the antiserum raised against high MW inhibin was able to neutralize, totally, the biological effect of high MW inhibin, and only, partially, the biological effect of low MW inhibin.