The Demise of John Hageman

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Abstract
ON March 24, 1968, Mr. John Hageman, the index patient with Hageman trait, died unexpectedly 12 days after sustaining fractures of the left ischium and ilium. The cause of death was pulmonary embolism.Case HistoryMr. Hageman, a freight brakeman, was first studied in 1953, when he was 37 years old, because a prolonged clotting time was detected in preparation for surgery.1 He had had symptoms of peptic ulcer since 1943, but was otherwise asymptomatic. Neither he nor his family had had a bleeding tendency, and he had not bled excessively after tonsillectomy, dental extractions or injuries. Partial gastrectomy and . . .