Effects of Total Body Irradiation Upon Lipoprotein Metabolism
Open Access
- 28 February 1953
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 172 (3) , 579-587
- https://doi.org/10.1152/ajplegacy.1953.172.3.579
Abstract
Lipoprotein levels were detd. ultracentrifugally in 49 rabbits before and 30 hrs. after X-irradiation with 800-900 r. The lipoprotein changes were characterized as to amount and Sf class. There is an excellent correlation between high level of total lipoprotein 30 hrs. after irradiation and subsequent death of the animal. A serum opalescence is associated with low-density lipoprotein only, not with total lipoprotein level. Changes in the lipoprotein levels after irradiation are consistent with the theory of conversion of low-density lipoprotein to higher density components. Injn. of heparin after irradiation hastens the return of lipoprotein levels to normal values. Injn. of toluidine blue produces changes in the lipoprotein pattern similar to those shown after irradiation.Keywords
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