Synthesis and Biological Activity of Some New Diarylsulphides and Diarylsulphones Containing Amino Acid Moieties, Part I
Open Access
- 1 August 1979
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 34 (8) , 1149-1153
- https://doi.org/10.1515/znb-1979-0822
Abstract
4' -Nitro -4-aminodipheny lsulphide (1a) and/or 2'-nitro-4-amino-diphenylsulphide (1b) react with chloroacetylchloride giving 4-chloroacetylamino-diarylsulphides (2a, b) which undergo facile reaction with different amines and hydrazine yielding the 4-glycylamino and 4-hydrazinoacetylaminodiphenylsulphides (3) and (5). Two moles of 2 react with one mole of piperazine and/or hydrazine to give 1,4-Bis(p-N-(p'-nitrodiphenylsulphido)(amino- carbonylmethylene)piperazino (4) and 1,2-Bis(p-N-(o'-nitro-diphenylsulphido)(aminocar- bonylmethylene)hydrazine (6). On condensation of 5 with aromatic aldehydes yielded new Schiff bases (7). Oxidation of 3, 4, 6 and 7 using H2O2/CH3COOH mixtures furnished the corresponding diarylsulphones 8, 9, 10 and 11, respectively. The biological activity of some of the prepared compounds were screened against some strains of bacteriaThis publication has 1 reference indexed in Scilit:
- β-(N-Piperazino)dimethylacetanilides and Their Local Anesthetic ActivityJournal of Medicinal Chemistry, 1966