IFN‐γ and TNF‐α secretion by CD4+ and CD8+ TCRαβ+ T‐cell clones derived early after allogeneic bone marrow transplantation

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Abstract
Secretion of the potentially antileukaemic cytokines IFN‐γ and TNF‐α was investigated for CD4 + and CD8 + TCRαβ+ T‐cell clones derived from 4 leukaemia patients 3–6 weeks after allogeneic BMT. We investigated cytokine secretion in response to the activation signal accessory cells + phytohaemagglutinin + Interleukin 2. All clones derived after BMT were capable of IFN‐γ and TNF‐α secretion, and both for CD4+ (n = 96) and CD8+ (n = 8) T cells quantities of IFN‐γ and TNF‐α were significantly correlated with one another. When comparing the overall results for posttransplant and normal T‐cell clones derived from 2 bone marrow donors (n = 65), both CD4+ and CD8+ TCRαβ+ T‐cell clones showed increased IFN‐γ production, and CD4+ but not CD8+ clones showed a decreased TNF‐α secretion. The results suggest that noncytotoxic T cells derived after allogeneic BMT can produce IFN‐γ and TNF‐α and may thus be capable of mediating antileukaemic effects.

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