REDUCTION OF PLASMA TRIIODOTHYRONINE (T3) INDUCED BY PROPRANOLOL
- 1 June 1977
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 6 (6) , 405-410
- https://doi.org/10.1111/j.1365-2265.1977.tb03322.x
Abstract
SUMMARY: The effect of propranolol on plasma triiodothyronine (T3), thyroxine (T4) and triiodothyronine uptake by Sephadex G‐25 (RT3U%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum T3 which began 60 min after administration. No significant changes were observed in T4 and RT3U% values. Plasma T3 levels remained suppressed during a 5 day course of treatment with propranolol. These results suggest that propranolol has a direct effect on peripheral metabolism of T3 rather than on thyroid hormone secretion.This publication has 15 references indexed in Scilit:
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