The development of animal cap cells in Xenopus: a measure of the start of animal cap competence to form mesoderm

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Abstract
Grafting, together with tissue identification by monoclonal antibodies, has been used to study the allocation of Xenopus animal cap cells to the ectodermal or mesodermal lineages. Animal cap cells become responsive at stage and lose responsiveness to mesodermal induction at, or just after, stage (depending on the batch of embryos). The ability of the vegetal yolky cells to induce mesoderm disappears between stages and 11. It is present at stage 6– and may exist before this. The emergence of competence to respond at stage , coupled with the fact that the endoderm is already capable of induction at this stage, suggests that mesodermal induction begins at this point in the intact embryo.