A model for evaluation of the peroral insulin therapy: Short-term treatment of alloxan diabetic rats with oral water-in-oil-in-water insulin emulsions.

Publisher Website
Google Scholar
Abstract
Alloxan diabetic rats with fasting blood glucose levels above 300 mg/100 ml were treated with oral administration of water-in-oil-in-water (W/O/W) insulin emulsions at a dose of 50 U[units]/100 g body wt, 3 times daily for 10-14 days. The course of diabetes was followed by determinations of glucose levels in blood and urine. During treatment with oral W/O/W insulin emulsions, daily excretion of urinary glucose decreased by about 30-40% (2-3 g/day) in all of the 5 rats studied, and returned to the pre-treatment levels after the treatment was discontinued. During treatment, a significant reduction in fasting blood glucose levels was observed in 4 out of 5 rats, a decrease of 18-44%. Quantitative estimates suggested that the effectiveness of 50 U/100 g of oral W/O/W insulin emulsions was comparable to that after i.m. regular insulin at a dose of 0.5 U/100 g. Although oral W/O/W insulin emulsions are still of low efficiency, diabetes can probably be controlled by effective oral insulin preparations.

This publication has 1 reference indexed in Scilit: