NAPROXEN AND INDOMETHACIN IN THE TREATMENT OF PRIMARY DYSMENORRHEA
- 11 January 1979
- journal article
- clinical trial
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 58 (S87) , 87-89
- https://doi.org/10.3109/00016347909157797
Abstract
The efficacy of naproxen and indomethacin in the treatment of dysmenorrhea was compared in a double-blind, cross-over study. Both drugs were given to 24 female undergraduates with severe primary dysmenorrhea in four consecutive cycles in a randomized schedule. Both drugs were equally effective. Good or moderate overall relief was achieved in 73% of 48 cycles treated with indomethacin and in 61% of the 48 cycles treated with naproxen. The difference was not statistically significant. Gastrointestinal side-effects occurred in 5 and 7 patients during naproxen and indomethacin treatment respectively. Central nervous system side-effects, dizziness, headache, tiredness, were more common with indomethacin than with naproxen (pp<0.05). Only one patient discontinued the treatment because of side-effects.Keywords
This publication has 3 references indexed in Scilit:
- Endogenous levels of prostaglandin F2α and its main metabolites in plasma and endometrium of normal and dysmenorrheic womenAmerican Journal of Obstetrics and Gynecology, 1978
- Treatment of Primary Dysmenorrhea with Prostaglandin Synthetase Inhibitors—a Promising Therapeutic AlternativeActa Obstetricia et Gynecologica Scandinavica, 1978
- Indomethacin in the treatment of primary dysmenorrhoeaArchiv für Gynäkologie, 1978