Protection of histidine side-chains with π-benzyloxymethyl- or π-bromobenzyloxymethyl-groups
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 648-649
- https://doi.org/10.1039/c39810000648
Abstract
N(α)-t-Butoxycarbonyl-N(π)-benzyloxymethyl-L-histidine (1) and N(α)-t-butoxycarbonyl-N(π)-4-bromo-benzyloxymethyl-L-histidine (2) have been prepared and shown to be suitable derivatives for peptide synthesis with histidine; the synthetic intermediates had convenient, physical properties, no side reactions were encountered, and the final deprotection proceeded smoothly under mild conditions.Keywords
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