MECHANISMS OF TOLERANCE IN MURINE RADIATION BONE MARROW CHIMERAS

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Abstract
Spleen cells from a series of allogeneic bone marrow chimeras were sensitized in vitro with stimulator cells from major histocompatibility complex recombinant strains of mice. The combinations were chosen such that both tolerated (host or donor) and nontolerated (3rd-party) antigens were present on the same stimulator cells in order to determine whether the tolerated host antigens might elicit nonspecific suppressor mechanisms affecting the cell-mediated lympholysis (CML) response to the nontolerated antigens. No evidence for such non-specific suppression was obtained in several types of assays. If suppressor mechanism exist that mediate such tolerance in mature allogeneic chimeras then these mechanisms must be highly antigen-specific.

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