alpha 1 Antitrypsin (PI) allotypes in rheumatoid arthritis.
Open Access
- 1 June 1986
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 45 (6) , 450-453
- https://doi.org/10.1136/ard.45.6.450
Abstract
Alpha 1 Antitrypsin (PI) phenotypes were defined in 144 patients with rheumatoid arthritis (RA) and in 223 normal controls. The frequencies of the rare F, S, and Z variants were similar in RA and control groups. No relationships were found between PI allotypes and rheumatoid disease severity or autoantibody titre. The PI M1M2 phenotype was increased in frequency in the RA group, and phenotype frequencies in DR4 positive and negative disease were similar. These results support the suggestion that genes on the 14th chromosome which are linked to PI predispose to RA.This publication has 15 references indexed in Scilit:
- Gm and Km allotypes in rheumatoid arthritis.Annals of the Rheumatic Diseases, 1985
- Genes for immunoglobulin heavy chains and for α1-antitrypsin are localized to specific regions of chromosome 14qNature, 1982
- Association of severe rheumatoid arthritis with heterozygosity for α‐antitrypsin deficiencyClinical Genetics, 1980
- ALPHA1-ANTITRYPSIN IN ADULT RHEUMATOID ARTHRITISThe Lancet, 1979
- Pi phenotypes of alpha1‐antitrypsin in Southern England: Identification of M subtypes and implications for genetic studiesClinical Genetics, 1979
- α1-ANTITRYPSIN PHENOTYPES IN RHEUMATOID ARTHRITIS AND ANKYLOSING SPONDYLITISThe Lancet, 1977
- α1-ANTITRYPSIN PHENOTYPES IN FIBROSING ALVEOLITIS AND RHEUMATOID ARTHRITISThe Lancet, 1977
- ALPHA-1 ANTITRYPSIN PHENOTYPES IN RHEUMATOID ARTHRITISThe Lancet, 1977
- ALPHA-1-ANTITRYPSIN PHENOTYPES AND RHEUMATIC DISEASESThe Lancet, 1977
- Obstructive pulmonary disease in rheumatoid arthritisArthritis & Rheumatism, 1976