Effect of Fasting or Underfeeding on Glucose Tolerance of Rats.

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Abstract
Rats fasted for 1-6 days failed to show a progressive decrease of oral glucose tolerance. Return of blood sugar levels to normal after intravenous glucose was somewhat delayed after 1-6 days of fasting as compared with the fed state, but not proportionately with the duration of the fast. Prolonged acute fasting therefore did not lead to typical "starvation diabetes" in rats. Chronically underfed rats fasted for 1 day and given glucose orally or intravenously exhibited a more fleeting elevation of blood sugar than ad libitum fed -fasted controls. This difference was not associated with any marked deficiency in hepatic glycogen formation from fed glucose, nor with glycosuria.