Structural and Genetic Analysis of the BldB Protein of Streptomyces coelicolor
- 1 August 2002
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 184 (15) , 4270-4276
- https://doi.org/10.1128/jb.184.15.4270-4276.2002
Abstract
We have demonstrated that the bldB gene of Streptomyces coelicolor is required for the formation of aerial hyphae and the synthesis of antibiotics. We also found that BldB forms a higher-order complex (most likely a dimer) and that amino acid residues 20 to 78 are important for this interaction. This region is conserved in the BldB family, suggesting that dimer formation may be a common feature of these proteins.Keywords
This publication has 22 references indexed in Scilit:
- Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductasesPublished by Elsevier ,2003
- An oligopeptide permease responsible for the import of an extracellular signal governing aerial mycelium formation in Streptomyces coelicolorMolecular Microbiology, 1996
- The bld mutants of Streptomyces coelicolor are defective in the regulation of carbon utilization, morphogenesis and cell–cell signallingMolecular Microbiology, 1996
- GENETICS OF DIFFERENTIATION IN STREPTOMYCESAnnual Review of Microbiology, 1993
- Extracellular complementation of a developmental mutation implicates a small sporulation protein in aerial mycelium formation by S. coelicolorCell, 1991
- BACTERIAL MUTATOR GENES AND THE CONTROL OF SPONTANEOUS MUTATIONAnnual Review of Genetics, 1976
- A Morphological and Genetic Mapping Study of Bald Colony Mutants of Streptomyces coelicolorJournal of General Microbiology, 1976
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- A theory of gel filtration and its exeperimental verificationJournal of Chromatography A, 1964