Mucoepidermoid Carcinoma of Uterine Cervix Stage IB
- 1 October 1990
- journal article
- research article
- Published by Wolters Kluwer Health in International Journal of Gynecological Pathology
- Vol. 9 (4) , 316-324
- https://doi.org/10.1097/00004347-199010000-00003
Abstract
Summary: Twelve women with mucoepidermoid carcinoma of the cervix uteri were followed for 2–15 years after diagnosis. Three patients died within 14 months. All had lymph node metastases and/or vascular involvement and exhibited tumor invasion to a depth of 1.2–3.2 cm. Mucoepidermoid carcinoma is defined as a tumor with the appearance of squamous cell carcinoma without any glandular pattern and with demonstrable intracellular mucin. The mucin is best demonstrated by alcian blue and periodic acid–Schiff-diastase. In 265 cases of squamous cell carcinoma, stage IB, lymph node metastases were present in 14%. In the cases of mucoepidermoid carcinoma, the prevalence of nodal metastases was 33%. Because mucoepidermoid carcinomas appear to be more aggressive lesions than squamous cell carcinomas are, it may be advisable to stain all cervical squamous carcinomas for mucin if they demonstrate finely vacuolated cytoplasm and lack peripheral palisading. Immunohistochemical studies for carcinoembryonic antigen (CEA), keratin, and epithelial membrane antigen were positive in all tumors to varying degrees. The detection of CEA may be of additonal help in establishing a diagnosis.Keywords
This publication has 4 references indexed in Scilit:
- Mucin production in cervical intraepithelial neoplasia and in stage 1b carcinoma of cervix with pelvic lymph node metastasesBJOG: An International Journal of Obstetrics and Gynaecology, 1987
- Mucin Production in Defining Mixed Carcinoma of the Uterine CervixInternational Journal of Gynecological Pathology, 1985
- Immunocytochemical Localization of Carcinoembryonic Antigen (CEA), Alpha-Fetoprotein (AFP), and Human Chorionic Gonadotropin (HCG) in Cervical NeoplasiaAmerican Journal of Clinical Pathology, 1983
- Incidence, histology, and response to radiation of mixed carcinomas (adenoacanthomas) of the uterine cervixCancer, 1956