Softening of semisynthetic suppository bases
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 17 (8) , 1083-1096
- https://doi.org/10.3109/03639049109043846
Abstract
The melting process of seventeen semisynthetic suppository bases has been evaluated by using a classical open capillary method together with differential scanning calorimetry and rheological analysis, in order to establish a physical mechanism for their premature softening. The presence in these materials of a mixture of different fat components with divergent melting points, as detected by the presented methods, satisfactorily explains this phenomenon.Keywords
This publication has 2 references indexed in Scilit:
- Physical stability of semisynthetic suppository basesJournal of Pharmaceutical Sciences, 1980
- Polymorphic changes in mixtures of confectionery fatsJournal of Oil & Fat Industries, 1976