Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N‐sulfate content
- 1 November 1981
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 15 (6) , 819-827
- https://doi.org/10.1002/jbm.820150606
Abstract
Addition of chlorosulfonyl isocyanate to CC bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.This publication has 11 references indexed in Scilit:
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