1-Halobenzyl-1H-indazole-3-carboxylic acids. A new class of antispermatogenic agents

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Abstract
The synthesis of a series of halogenated 1-benzylindazole-3-carboxylic acids and related derivatives is described. These compounds were studied in rats for their effect on testicular weight and on the inhibition of spermatogenesis. Many of the derivatives, but in particular 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid, 1-(2,4-dibromobenzyl)-1H-indazole-3-carboxylic acid, 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylic acid, and their glycerol esters, showed potent antispermatogenic activity.

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