Studies of Rhodium(II) Carboxylates as Potential Antitumor Agents

1 April 1974

journal article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 145 (4) , 1278-1283
https://doi.org/10.3181/00379727-145-37996

Abstract

Rhodium (II) acetate and rhodium (II) propionate were found to be antineoplastic agents. Both compounds inhibited DNA and RNA synthesis. The rhodium(II) propionate was also found to block de novo purine biosynthesis. Binding studies employing the carbon-14-labeled rhodium (II) acetate showed binding to DNA (poly A), and two proteins.

Keywords

PROTEINS
ANTITUMOR AGENTS
ANTINEOPLASTIC AGENTS
RHODIUM
BINDING STUDIES
PURINE BIOSYNTHESIS
COMPOUNDS INHIBITED
SHOWED BINDING
ACETATE SHOWED

This publication has 0 references indexed in Scilit: