Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
Open Access
- 1 January 1999
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 79 (4) , 505-508
- https://doi.org/10.1254/jjp.79.505
Abstract
We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.Keywords
This publication has 13 references indexed in Scilit:
- Inhibitory Effect of Cordyceps sinensis on Spontaneous Liver Metastasis of Lewis Lung Carcinoma and B16 Melanoma Cells in Syngeneic MiceThe Japanese Journal of Pharmacology, 1999
- The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordyceps sinensis Part IThe Journal of Alternative and Complementary Medicine, 1998
- Effects of a water-soluble extract ofCordyceps sinensis on steroidogenesis and capsular morphology of lipid droplets in cultured rat adrenocortical cellsJournal of Cellular Biochemistry, 1998
- Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley ratToxicology, 1997
- Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liverHepatology, 1996
- Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liverHepatology, 1996
- Effects of the Mycelial Extract of Cultured Cordyceps Sinensis on In Vivo Hepatic Energy Metabolism in the MouseThe Japanese Journal of Pharmacology, 1996
- Vitamin A or Zymosan Pretreatment Attenuates α-Naphthylisothiocyanate-Induced Liver InjuryToxicology and Applied Pharmacology, 1995
- Cordyceps Sinensis-I as an immunosuppressant in heterotopic heart allograft model in ratsJournal of Tongji Medical University, 1990
- A new method to monitor Kupffer-cell function continuously in the perfused rat liver. Dissociation of glycogenolysis from particle phagocytosisBiochemical Journal, 1990