TREATMENT OF CONGESTIVE HEART FAILURE AND ANGINAL SYNDROME WITH CHOLINE THEOPHYLLINATE

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Abstract
In this study it was our task to evaluate the effectiveness of choline theophyllinate for the treatment of the anginal syndrome and congestive heart failure. Since the introduction of xanthines for the treatment of these disorders there has been reluctance on the part of some investigators, including ourselves, to accept the value of these medicaments for this purpose. In spite of this, however, their use has been widespread and in many cases has been of considerable benefit. The xanthine preparation that has the greatest popularity at present is theophylline ethylenediamine or aminophylline. No one questions the efficacy of the parenteral use of this medicament, but oral and rectal use leave much to be desired. The disadvantages of aminophylline are several. Foremost among them is the unpredictability of achieving a desired therapeutic effect when the drug is administered orally. This reflects the difficulty in attainment of a good blood level because

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