Effects of Excess Dietary d/-Methionine and/or /-Arginine on Rats

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Abstract
The addition of excessive amts. of DL-methionine (4.8%) to a diet containing casein (12%) decreased liver and body fat and the retention of N in the rat, and produced a loss in body wt. Retention of N was increased in the liver and the kidneys, and the kidneys were hypertrophied. Addition of an excess of L-arginine (1.7%) to the casein diet had little effect on the retention of N, but the arginine counteracted the effects of methionine on body wt. and kidney size when the 2 amino acids were added together, and increased the retention of N throughout the body . The increased excretion of creatinine suggested a speeding up of the methylating processes.