Vasorelaxant Drugs and Cerebrovascular Disease

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Abstract
Evidence that cerebral vasospasm occurs in animals and in humans is reviewed, together with reports that such vasospasm is preventable by a number of pharma-cologic agents. Some of the latter, including cyclandelate, isoxsuprine, and nylidrin, do not cause hypotension in therapeutic dosage. Evaluation of such vasorelaxants is possible to their ability to block the eeg build-up response to hyperventilation. Recent reports are cited of the effectiveness and safety of these drugs in treatment of cerebrovascular disorders due to or complicated by vascular spasm.