A CONTROLLED FIELD TRIAL OF EFFECTIVENESS OF CHOLERA AND CHOLERA EL TOR VACCINES IN PHILIPPINES

  • 1 January 1967
    • journal article
    • research article
    • Vol. 37  (5) , 703-+
Abstract
A controlled field trial on some 584 000 people in an endemic cholera El Tor area in the Philippines demonstrated that cholera vaccines gave moderate protection of short duration. Injection of a single dose of vaccine prepared from either Vibrio cholerae or El Tor vibrios gave over 50% protection for the 1st 2 months. The immunity conferred by the V. cholerae vaccine declined rapidly after 3 to 4 months. The effectiveness of the El Tor vaccine continued for 6 months. An oil-adjuvant vaccine prepared from V. cholerae conferred an equally high degree of protection for a longer period of time, but, its use could not be recommended due to severe vaccination reactions.