Failure to detect circulating immune complexes in allergic patients on injection therapy

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Abstract
Injection therapy for allergic diseases may create an environment conducive to circulating immune complex formation. Sera of 11 patients receiving injection therapy was examined for presence of circulating immune complexes. A sensitive [Burkitt''s lymphoma] Raji cell radioimmune assay was used to examine the sera prior to and 4, 8 and 24 h after allergenic injection. Levels measured in these sera were compared to values obtained from 42 healthy controls. Of 11 allergic patients receiving injection therapy, 10 had values within the normal range prior to maintenance injection. These 10 patients also had normal values for circulating immune complexes at each interval after maintenance injection. Circulating immune complexes are apparently not a routine consequence of injection therapy for allergic disease.

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