Variable attenuation of amphetamine effects by lithium

Abstract
In an open study of 8 subjects, approximately half showed some attenuation of CNS stimulant effects of amphetamine after Li pretreatment. Two showed specific blockade of euphoria, with persistence of some CNS stimulant effects. In 3 subjects Li did not appear to affect the response to amphetamine. Li caused significant attenuation of the amphetamine-induced increase in systolic blood pressure for the group as a whole.