CD3+ CD8+ CD56− clonal large granular lymphocyte leukaemia and HIV infection
- 1 August 1997
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 98 (2) , 444-445
- https://doi.org/10.1046/j.1365-2141.1997.1913009.x
Abstract
High-grade malignant lymphomas associated with HIV infection are usually derived from B lymphocytes. Although a broad spectrum of T-cell-derived malignancies has been described, no case of monoclonal T large granular lymphocyte leukaemia has been reported to date. We report a case of clonal T-LGL (CD3+, CD4-, CD8+, CD56-, CD57+) in an HIV-infected. HTLV1/2-negative individual. Large granular lymphocytes are thought to represent activated cytotoxic T lymphocytes. HIV infection, as previously reported for HTLV1/2, may represent a pathway of antigen activation and lead to clonal expansion of T large granular lymphocytes.Keywords
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