The haemoglobins of the human foetus and infant. Electrophoretic and spectroscopic differentiation of adult and foetal types

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Abstract
The differences in properties between fetal and adult hemoglobins, when studied by electrophoretic and spectrophotometric methods, were used to follow their distribution in human blood from early prenatal life. Adult oxyhemoglobin shows greater anodic mobility than fetal oxyhemoglobin in phosphate at pH 7.1, 8.0 and 8.8. The findings of Jope on the differences in spectroscopic characteristics between the 2 types of hemoglobin were confirmed and extended. At 20 weeks of pregnancy fetal oxyhemoglobin contains at least 6% of "adult" type; at birth, about 20%; at 2 months after birth, about 50%; and at 4 months, between 80 and 90% of the "adult" type.