MORPHOLOGICAL CLASSIFICATION OF MOUSE-LIVER TUMORS BASED ON BIOLOGICAL CHARACTERISTICS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (10) , 3918-3923
Abstract
Examination of 3 strains of inbred mice suggested that specific morphological types of hepatic tumors are the result of genetic predisposition while other types of tumors are associated with exposure to chemical carcinogens. A simple classification system is proposed. Additional studies indicated that a putative promoting agent, such as phenobarbital, increased the incidence of those tumor types usually associated with spontaneous appearance and only in strains with a genetic predisposition to spontaneous tumorigenesis. Carcinogens induce an increase in all types of tumors.