Molecular epidemiology of long-term colonization of Candida albicans strains from HIV-infected patients
- 19 August 2005
- journal article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 134 (2) , 265-269
- https://doi.org/10.1017/s0950268805004905
Abstract
Twenty-one Candida albicans isolates from three HIV-infected patients were collected over a period of 3 years and characterized for fluconazole susceptibility, infectivity and genetic relatedness. Fluconazole resistance was found in five isolates, four exhibited dose-dependent susceptibility and the remainder were fully susceptible to this agent. Pulsed-field gel electrophoresis of SfiI restriction digests of the genomic DNA from the isolates revealed that isolates from the same swab specimen were identical despite differences in susceptibility to fluconazole and isolates recovered over time from the three patients retained clonally related DNA fingerprints within each patient. This small-scale study confirms the persistence of oral colonization of C. albicans strains in HIV-infected patients. Clinical data also suggests that the primary infecting strain may become a persistent colonist in the oral cavity once the immune function of the patient has been restored.Keywords
This publication has 16 references indexed in Scilit:
- Colonization of Human Immunodeficiency Virus-Infected Outpatients in Taiwan with Candida SpeciesJournal of Clinical Microbiology, 2005
- Comparison of four molecular typing methods to assess genetic relatedness of Candida albicans clinical isolates in TaiwanJournal of Medical Microbiology, 2005
- Species identification of medically important fungi by use of real-time LightCycler PCRJournal of Medical Microbiology, 2003
- A Prospective Observational Study of Candidemia: Epidemiology, Therapy, and Influences on Mortality in Hospitalized Adult and Pediatric PatientsClinical Infectious Diseases, 2003
- Persistence of Oropharyngeal Candida albicans Strains with Reduced Susceptibilities to Fluconazole among Human Immunodeficiency Virus-Seropositive Children and Adults in a Long-Term Care FacilityJournal of Clinical Microbiology, 2003
- National Surveillance of Nosocomial Blood Stream Infection Due to Species of Candida Other than Candida albicans: Frequency of Occurrence and Antifungal Susceptibility in the SCOPE ProgramDiagnostic Microbiology and Infectious Disease, 1998
- Molecular mechanisms of drug resistance in fungiTrends in Microbiology, 1994
- The prevalence of oral lesions in HIV-infected homosexual and bisexual menAIDS, 1991
- Fungal Infections in Patients with AIDS and AIDS-related ComplexScandinavian Journal of Infectious Diseases, 1986
- Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1984