Long-time penicillamine-treatment in Amyotrophic Lateral Sclerosis with parallel determination of lead in blood, plasma and urine

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Abstract
Six ALS-patients were given long-term penicillamine treatment. A rapid, long-lasting increase in urinary lead was provoked, whereas whole blood and plasma lead were unchanged. In four patients, the progress did not change markedly, one patient deteriorated rapidly and in one patient the progression slowed down after one and a half years of treatment.