Mutagenicity of 4,4′-methylene-bis-(2-chloroaniline) “MOCA” and its N-acetyl derivatives in S. typhimurium
- 1 February 1985
- journal article
- Published by Springer Nature in Internationales Archiv für Arbeitsmedizin
- Vol. 55 (2) , 169-174
- https://doi.org/10.1007/bf00378379
Abstract
4,4′-methylene-bis-(2-chloroaniline) (“MOCA”) and two identified urinary N-acetyl and N,N′-diacetyl derivatives were tested in a Salmonella/mammalian microsome assay. No mutagenic activity was observed without rat liver S9 mix activation. In the presence of rat liver S9 mix, the chemicals were mutagens, but the mutagenicity of N-acetyl derivatives to strain TA 100 was reduced when compared to that of “MOCA”, and a greater amount of S9 was required to exhibit the mutagenicity of the N,N′-diacetyl-“MOCA”. These data suggest that N-acetylation does not account for the mutagenic effectiveness of “MOCA”.Keywords
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