γ-L-Glutamyl-O-acyl-L-serylglycine derivatives: synthesis, purification and evaluation as inhibitors of glyoxalases
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 5,p. 639-643
- https://doi.org/10.1039/p19920000639
Abstract
Oxygen ester analogues of S-D-lactoylglutathione, γ-L-glutamyl-O-acyl-L-serylglycine derivatives, were synthesised and evaluated as inhibitors of glyoxalase II. They were competitive inhibitors where the inhibition constant Ki, decreased with increase in acyl chain length. γ-L-Glutamyl-O-acyl-L-serylglycine derivatives also inhibit glyoxalase I. These compounds provide a novel route to glyoxalase II inhibitors for cancer chemotherapy.Keywords
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