Some Examples of Dose-Response Studies in Chemical Carcinogenesis
- 1 January 1976
- journal article
- Published by S. Karger AG in Oncology
- Vol. 33 (2) , 66-71
- https://doi.org/10.1159/000225107
Abstract
Three studies of DRUCKREY and his group, on diethylnitrosamine and 4-dimethylaminostilbene, are described. In a recent experiment, urethane was given chronically to rats and mice, at doses between 100 and 12,500 mug/kg/day. The results in rats were evaluated with the Mantel-Bryan procedure; risk estimates greatly differed, depending on the slope used for calculation.Keywords
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