9-(2-Fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents
- 1 May 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 31 (5) , 1005-1009
- https://doi.org/10.1021/jm00400a019
Abstract
Several substituted aryl and 6-alkylamino analogues of the anticonvulsant purine 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine (1) were synthesized and tested dor anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Derivatives with a second fluoro substituent in the 5- or 6-position of the aryl moiety were very active with ip ED50''s that ranged from 2 to 4 mg/kg. Congeners in which the purine 6-substituent was varied among a number of alkylamino groups possessed potent activity against MES that was comparable to or several times better than phenytoin.This publication has 1 reference indexed in Scilit:
- Enzyme inhibitors. XIX. Synthesis of some 1-hydroxy-2-hydroxymethyl-4-(6)substituted-9-purinyl)cyclohexanes as nucleoside analogsJournal of Medicinal Chemistry, 1968