Antiinflammatory agents protect opossum esophagus during radiotherapy
- 1 October 1982
- journal article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 27 (10) , 923-928
- https://doi.org/10.1007/bf01316577
Abstract
Eighteen opossums received 2250 rad60Co to the entire esophagus and lower esophageal sphincter. Animals received treatment with 600 mg aspirin, 25 mg/kg hydrocortisone, or saline before irradiation and twice daily for 1 week after irradiation. At 10 days postirradiation, animals were evaluated for signs of acute esophagitis by esophagoscopy and barium esophagram. Each animal was then killed and the esophagus removed and evaluated histologically. Animals treated with either aspirin or hydrocortisone had significantly milder esophagitis than control irradiated animals.Keywords
This publication has 16 references indexed in Scilit:
- The Opossum as an Animal Model for Studying Radiation EsophagitisRadiology, 1979
- Elementary StatisticsInternational Statistical Review, 1977
- EFFECT OF IONIZING RADIATION ON PROSTAGLANDIN‐LIKE ACTIVITY IN TISSUESBritish Journal of Pharmacology, 1976
- Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.Proceedings of the National Academy of Sciences, 1976
- TREATMENT OF RADIATION-INDUCED GASTROINTESTINAL DISTRESS WITH ACETYLSALICYLATEThe Lancet, 1975
- Some characteristics of the prostaglandin synthesizing system in rabbit kidney microsomesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975
- ASPIRIN IN RADIATION-INDUCED DIARRHŒAThe Lancet, 1973
- Indomethacin and Aspirin abolish Prostaglandin Release from the SpleenNature New Biology, 1971
- Aspirin Selectively Inhibits Prostaglandin Production in Human PlateletsNature New Biology, 1971
- Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like DrugsNature New Biology, 1971