A Study on Erythrocyte Membrane Plasmalogen in Myotonic Dystrophy

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Abstract
Phospholipid classes that included plasmalogens of erythrocyte membranes in 7 myotonic dystrophy (MyD) patients and 7 normal controls were analyzed by HPLC [high performance liquid chromatography]. No significant difference in phospholipid classes was found between patients with MyD and normal controls, but there was a visible difference in peak profiles of compounds of the phosphatidylethanolamine class. Exposure to HCl and deacylation with mild alkaline were used. The area ratio of the plasmalogen form to the diacyl form in the phosphatidylethanolamine class of MyD erythrocyte membranes was significantly lower than that of normal controls. Fatty acid analyses showed that fatty acids of both phosphatidylethanolamine subclasses have less unsaturation in MyD.

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