THE INTERCONVERSION OF ESTRONE AND ESTRADIOL BY HUMAN TISSUE SLICES1,2,3

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Abstract
Studies of estrogen metabolism in animals have limited application to man because of the different metabolic pathways in different species. For example, estriol has been recovered only from human sources; epiestradiol is a product of rabbit and equine metabolism and the naphtholic estrogens are peculiar to equine species (Pincus and Pearlman, 1943). Comparative studies of the in vitro metabolism of estrogens by human and animal tissues have not been extensive, but species differences have been noted (Twombly and Taylor, 1942; Szego and Samuels, 1943; Samuels and McCauley, 1946). The biochemical interrelationships between steroid hormones and cellular function is at present a matter of intense interest. In order to measure directly the metabolic activity of normal and neoplastic tissues of man, an investigation of estrogen metabolism in such tissues was undertaken. The data revealed that the inter con version of estrone and estradiol as well as the further degradation

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