Parasitism and Protocells: Tragedy of the Molecular Commons

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Abstract
This chapter describes the top-down approach of simplifying small or minimal genomes to construct an artificial cell. First, it discusses the concept of minimal genomes. This is followed by an overview of the past and current efforts in comparative and evolutionary genomics. The metabolic capacities of minimal and natural reduced genomes are also discussed. Finally, the chapter outlines possible implications for the assembly of top-down protocells.

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