Y-Linked Genes and Male-Sex Determination

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Abstract
It is generally assumed that a Y chromosome must be present for testes to be formed. Presumably, only a small part of the Y chromosome contains the genes necessary for male development, since subjects with an isochromosome of the long arm of the Y, who thereby lack the short arm of the Y, have the Turner-syndrome phenotype. The nature of these vital genes, however, has remained a mystery. It is thus a matter of considerable interest to learn of an antigen (the H-Y antigen) that behaves as if determined by a Y-linked gene and that may help unravel some of . . .

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