Review article: the Molecular Adsorbents Recirculating System (MARS) in liver failure
- 7 November 2002
- journal article
- review article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 16 (s5) , 32-38
- https://doi.org/10.1046/j.1365-2036.16.s5.5.x
Abstract
In recent years different artificial liver support systems are being developed for use in patients with acute decompensation of chronic liver disease or acute liver failure. The molecular adsorbents recirculating system (MARS), a device in which patient's blood is dialysed across an albumin‐impregnated membrane against a recirculated albumin‐containing solution, seems to be effective in removing albumin‐bound toxins, such as fatty acids, bile acids and bilirubin. Although the clinical experience with MARS is scarce, some pilot studies have reported its effectiveness at improving liver function and hepatic encephalopathy in patients with acute decompensation of chronic liver disease, and renal function in patients with hepatorenal syndrome type I. Data regarding MARS experience in acute liver failure and in primary graft dysfunction are encouraging but limited. Its real usefulness in these settings is, at present, under evaluation in randomized controlled clinical trials.Keywords
This publication has 49 references indexed in Scilit:
- Hemodynamic changes during a single treatment with the molecular adsorbents recirculating system in patients with acute-on-chronic liver failureLiver Transplantation, 2001
- Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failureLiver Transplantation, 2001
- Albumin dialysis with the M.A.R.S. (Molecular Absorbent Recirculating System) for a patient with acute liver failure due to paracetamol intoxication: A case-reportZeitschrift für Gastroenterologie, 2001
- Successful Clinical Application of Extracorporal Albumin Dialysis in a Patient with Benign Recurrent Intrahepatic Cholestasis (BRIC)Zeitschrift für Gastroenterologie, 2001
- Improvement of hepatorenal syndrome with extracorporeal albumin dialysis mars: Results of a prospective, randomized, controlled clinical trialLiver Transplantation, 2000
- Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteriaLiver Transplantation, 2000
- Molecular Adsorbent Recycling System (MARS): Clinical Results of a New Membrane‐Based Blood Purification System for Bioartificial Liver SupportArtificial Organs, 1999
- Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathyJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1998
- AN ALBUMIN DIALYSATE HEMODIAFILTRATION SYSTEM FOR THE CLEARANCE OF UNCONJUGATED BILIRUBINAsaio Journal, 1997
- Hepatorenal Disorders: Role of the Sympathetic Nervous SystemSeminars in Liver Disease, 1994