Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines
- 1 January 1990
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 07 (7) , 712-718
- https://doi.org/10.1023/a:1015859320604
Abstract
The contributions of several proposed mechanisms by which fatty acids and amines might increase skin permeation rates were assessed. Permeation rates of model diffusants with diverse physicochemical...This publication has 17 references indexed in Scilit:
- Structure/Effect Studies of Fatty Acid Isomers as Skin Penetration Enhancers and Skin IrritantsPharmaceutical Research, 1989
- Penetration of Adenosine into Excised Human Skin from Binary Vehicles: The Enhancement FactorJournal of Pharmaceutical Sciences, 1988
- LIPOPHILIZATION OF HYDROPHILIC COMPOUNDS - CONSEQUENCES ON TRANS-EPIDERMAL AND INTESTINAL TRANSPORT OF TROSPIUM CHLORIDE1987
- Delivery of Theophylline into Excised Human Skin from Alkanoic Acid Solutions: A “Push-Pull” MechanismJournal of Pharmaceutical Sciences, 1987
- Enhanced percutaneous absorption of ionizable water-soluble drugs.1987
- Percutaneous absorption of indomethacin from mixtures of fatty alcohol and propylene glycol (FAPG bases) through rat skin: Effects of fatty acid added to FAPG base.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Mechanism of enhancement of percutaneous absorption of molsidomine by oleic acid.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Role of Stratum Corneum Lipid Fluidity in Transdermal Drug FluxJournal of Pharmaceutical Sciences, 1987
- Effect of Fatty Acids and Alcohols on the Penetration of Acyclovir Across Human Skin in VitroJournal of Pharmaceutical Sciences, 1985
- VEHICLE EFFECT ON TOPICAL DRUG DELIVERY .2. CONCURRENT SKIN TRANSPORT OF DRUGS AND VEHICLE COMPONENTS1983