Pneumocandins from Zalerion arboricola. III. Structure elucidation.

1 January 1992

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 45 (12) , 1875-1885
https://doi.org/10.7164/antibiotics.45.1875

Abstract

Pneumocandin B0 (6) and six related lipopeptides are antifungal and anti-Pneumocystis carinii agents from mutants of Zalerion arboricola, whose structures were determined mainly on the basis of spectroscopic analysis. They belong, along with pneumocandin A0 (L-671,329) previously isolated from these laboratories, to the echinocandin class of antifungal agents. The product from base-catalyzed ring opening involving the hemiaminal position of the dihydroxyornithine residue of B0, has been clearly defined as 6b. Modifications were limited to the 3-hydroxy-4-methylproline, 3,4-dihydroxyhomotyrosine and 4,5-dihydroxyornithine residues of pneumocandin A0.

Keywords

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