Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice
- 1 February 1977
- journal article
- research article
- Published by Wiley in Teratology
- Vol. 15 (1) , 25-32
- https://doi.org/10.1002/tera.1420150104
Abstract
Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1–3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to GDI and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.This publication has 32 references indexed in Scilit:
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