Alveolar Epithelial β2-Adrenergic Receptors
- 1 February 2008
- journal article
- review article
- Published by American Thoracic Society in American Journal of Respiratory Cell and Molecular Biology
- Vol. 38 (2) , 127-134
- https://doi.org/10.1165/rcmb.2007-0198tr
Abstract
Beta(2)-adrenergic receptors are present throughout the lung, including the alveolar airspace, where they play an important role for regulation of the active Na(+) transport needed for clearance of excess fluid out of alveolar airspace. beta(2)-adrenergic receptor signaling is required for up-regulation of alveolar epithelial active ion transport in the setting of excess alveolar edema. The positive, protective effects of beta(2)-adrenergic receptor signaling on alveolar active Na(+) transport in normal and injured lungs provide substantial support for the use of beta-adrenergic agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with emphasis on their role in the regulation of alveolar active Na(+) transport in normal and injured lungs.Keywords
This publication has 137 references indexed in Scilit:
- Respiratory syncytial virus induces insensitivity to β-adrenergic agonists in mouse lung epithelium in vivoAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
- In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injuryThorax, 2007
- β-Adrenergic Receptor Stimulation and Adenoviral Overexpression of Superoxide Dismutase Prevent the Hypoxia-mediated Decrease in Na,K-ATPase and Alveolar Fluid ReabsorptionJournal of Biological Chemistry, 2006
- Upregulation of Alveolar Epithelial Active Na + Transport Is Dependent on β 2 -Adrenergic Receptor SignalingCirculation Research, 2004
- Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor RecyclingPublished by Elsevier ,2001
- G Protein Signaling from Activated Rat Frizzled-1 to the β-Catenin-Lef-Tcf PathwayScience, 2001
- Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79Journal of Biological Chemistry, 2001
- E3KARP Mediates the Association of Ezrin and Protein Kinase A with the Cystic Fibrosis Transmembrane Conductance Regulator in Airway CellsJournal of Biological Chemistry, 2000
- Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and ResensitizationJournal of Biological Chemistry, 2000
- Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic ReceptorPublished by Elsevier ,1996