Potentiation of the thermic effect of insulin by exercise: differences between lean, obese, and noninsulin-dependent diabetic men

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Abstract
We studied the effects of prior high-intensity cycle exercise (85% VO2 max) on total energy expenditure (EE) and the thermic effect of insulin (TEI) in normal controls and in obese insulin-resistant and noninsulin-dependent diabetic (NIDDM) subjects. Normal controls, but not obese or NIDDM subjects, showed a significant increase (3–7%) in total EE 12–16 h after exercise (p < 0.05). Prior exercise increased lipid and decreased glucose oxidation in all groups. During low-dose insulin infusion (40 mU · M2 · min), prior exercise potentiated TEI in control and NIDDM subjects (p < 0.05), whereas obese subjects showed no response. During high-dose insulin infusion (400 mU · M2 · min), TEI was similar in NIDDM and control subjects but was significantly less in the obese group. In this study, we found a positive correlation between TEI and insulin-stimulated rates of glucose disposal (r = 0.91, p < 0.001). The predicted cost of glucose storage accounted for 42% of TEI.