CYTOPLASMIC INCLUSION BODIES IN CORTISOL-TREATED MAMMARY TUMORS OF C3H/Crgl MICE

Abstract
Following cortisol treatment of mammary-tumor-bearing C3H mice, cytoplasmic inclusion bodies frequently are visible in the tumor cells. Histo-chemical studies indicate that these inclusion bodies contain protein, RNA, and probably mucopolysaccharide, but no demonstrable DNA. Electron micrographs reveal that the inclusions are composed of large aggregations of the virus-like particles usually found in preneoplastic and neoplastic mouse mammary tissues.