Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins
Top Cited Papers
- 14 January 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 307 (5707) , 265-268
- https://doi.org/10.1126/science.1105416
Abstract
The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1–expressing endothelial cells of adjacent intersomitic vessels. Sema3E–plexin-D1 signaling did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation of Sema3E or plexin-D1 but not neuropilin-mediated Sema3 signaling disrupted vascular patterning. These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning.Keywords
This publication has 19 references indexed in Scilit:
- Semaphorin-Plexin Signaling Guides Patterning of the Developing VasculatureDevelopmental Cell, 2004
- PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular DevelopmentDevelopmental Cell, 2004
- To move or not to move?EMBO Reports, 2004
- Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2Genes & Development, 2004
- Class 3 semaphorins control vascular morphogenesis by inhibiting integrin functionNature, 2003
- Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular DevelopmentDevelopmental Cell, 2003
- SIGNALING AT THE GROWTH CONE: Ligand-Receptor Complexes and the Control of Axon Growth and GuidanceAnnual Review of Neuroscience, 2003
- PLEXIN‐D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesisDevelopmental Dynamics, 2002
- The Semaphorin 4D receptor controls invasive growth by coupling with MetNature Cell Biology, 2002
- Characterization of Neuropilin-1 Structural Features That Confer Binding to Semaphorin 3A and Vascular Endothelial Growth Factor 165Journal of Biological Chemistry, 2002